Molecular Mechanisms in Legionella Pathogenesis by Hubert Hilbi (English) Paperb

Description: Molecular Mechanisms in Legionella Pathogenesis by Hubert Hilbi Legionnaires disease, a potentially fatal type of pneumonia primarily affecting elderly and immuno-compromised persons, is caused by the ubiquitous environmental bacterium Legionella pneumophila. FORMAT Paperback LANGUAGE English CONDITION Brand New Publisher Description Legionnaires disease, a potentially fatal type of pneumonia primarily affecting elderly and immuno-compromised persons, is caused by the ubiquitous environmental bacterium Legionella pneumophila. This book offers authoritative reviews of different facets of its virulence, focusing on comparative phagocyte infection, virulence gene regulation, biochemical functions of effector proteins and cellular pathogen-host interactions, as well as host responses and immunity to L. pneumophila. Taken together, the contributions in this compilation provide a state-of-the-art overview of current insights into the molecular pathogenesis of the opportunistic and potentially fatal pathogen L. pneumophila. Table of Contents From amoeba to macrophages: exploring the molecular mechanisms of Legionella infection in both hosts.- The Legionella pneumophila two-component regulatory systems that participate in the regulation of Icm/Dot effectors.- Facets of small RNA-mediated regulation in Legionella pneumophila.- Type II secretion and Legionella virulence.- Effector translocation by the Legionella Icm/Dot type IV secretion system.- Modulation of small GTPases by Legionella.- Host lipidation: A mechanism for spatial regulation of Legionella effectors.- Phosphoinositides and the Legionella pathogen vacuole.- Legionella phospholipases implicated in virulence.- Cytotoxic glucosyltransferases of Legionella pneumophila.- Modulation of the ubiquitination machinery by Legionella.- Host signal transduction and protein kinases implicated in Legionella infection.- Mouse models of Legionnaires´ disease. Long Description Legionnaires disease, a potentially fatal type of pneumonia primarily affecting elderly and immuno-compromised persons, is caused by the ubiquitous environmental bacterium Legionella pneumophila . This book offers authoritative reviews of different facets of its virulence, focusing on comparative phagocyte infection, virulence gene regulation, biochemical functions of effector proteins and cellular pathogen-host interactions, as well as host responses and immunity to L. pneumophila . Taken together, the contributions in this compilation provide a state-of-the-art overview of current insights into the molecular pathogenesis of the opportunistic and potentially fatal pathogen L. pneumophila . " Feature Written by leading authorities in the field Provides an up-to-date and comprehensive overview Contributes to an in-depth-understanding of Legionnaires disease Details ISBN3662523000 Year 2016 ISBN-10 3662523000 ISBN-13 9783662523001 Format Paperback Imprint Springer-Verlag Berlin and Heidelberg GmbH & Co. K Place of Publication Berlin Country of Publication Germany Edited by Hubert Hilbi Publication Date 2016-08-23 DEWEY 616.241 Language English Media Book Illustrations 2 Illustrations, color; 17 Illustrations, black and white; X, 295 p. 19 illus., 2 illus. in color. Pages 295 Series Number 376 Author Hubert Hilbi Publisher Springer-Verlag Berlin and Heidelberg GmbH & Co. KG Edition Description Softcover reprint of the original 1st ed. 2014 Series Current Topics in Microbiology and Immunology Alternative 9783642405907 Audience Professional & Vocational We've got this At The Nile, if you're looking for it, we've got it. With fast shipping, low prices, friendly service and well over a million items - you're bound to find what you want, at a price you'll love! TheNile_Item_ID:137661241;

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